Wednesday, November 7, 2012

Four Is the Magic Number | Special Issue | The Link

Throughout the strikes, protests and general commotion of last spring, access to education was the concern du jour among all those who donned red squares to protest tuition hikes.

The fee increase, the argument went, would mean that students of limited means would be less able to obtain a university education.

But access to education depends on more than what?s in a 19-year-old?s bank account. With the hikes cancelled and post-secondary students back in class,?the accessibility question is now being asked about a new cohort of Quebecers?preschoolers.

The Quebec government has a history of investing in children before they start school. Since 1997, the province?s daycare subsidy program ensures a certain number of spaces for children to learn and be cared for during the day, either in family daycare centres, privately run facilities, or state-run centres de la petite enfance.

Quebec?s school boards also operate a small number of pre-kindergarten programs, and a handful of other early childhood initiatives like the Passe-partout program?which aims to implicate parents in their children?s development?try to bridge the gap.

But with funding shortages leading to a lack of spaces in these programs, some are falling through the cracks. This is especially true of those living in poverty, who experts say are also less likely to receive educational attention at home.

Still, one classic study, Michigan?s 1962 Perry Preschool Project, found that children from low-income backgrounds who attended high-quality preschool at ages three and four were more likely to do well in class, graduate high school and go on to post-secondary education than students who started school later.

With this in mind, the Conseil sup?rieur de l??ducation, an independent advisory body within the Quebec government, released a report in late October highlighting the need for more early childhood education in Quebec, focusing specifically on four-year-olds.

The CSE?s recommendations included the creation of more spaces for four-year-olds in the centres de la petite enfance, with priority given to low-income communities. It also recommended a series of measures to improve daycare quality, as well as the allotment of extra funds to support community-based early childhood initiatives.

?We found out that for children four years of age, about two-thirds of them had access to some form of service,? said Claude Lessard, president of the CSE. ?We know that that?s not enough.?

The CSE?s target is to give 90 per cent of four-year-olds in Quebec access to some form of regulated, educational childcare within five years? time.

Lessard explained that in low-income areas, many families don?t utilize daycare services, attributing this to a lack of available spaces, and to the perception that ?if you don?t work, you don?t send [your children] to a daycare centre.?

To deal with this inequity, the CSE recommends that more pre-kindergartens?currently offered to less than 10 per cent of four-year-olds province-wide?be put in place in schools in ?low-income areas. They also want daycare to be free of charge for all four-year-olds, regardless of parental income.

A Question of Funding

In a press release, newly appointed Education Minister Marie Malavoy has said she supports the CSE?s recommendations, adding that expanding the pre-kindergarten system will be a priority for her ministry.

For Jos?e Bouchard, president of the F?d?ration des commissions scolaires du Qu?bec, this is good news.

?In acting very early in the life of a child, we better the chances of success for those children,? said Bouchard, who represents Quebec?s francophone school boards.

?We know that children who repeat Grade One have a very high risk of not receiving their high school diploma. So [early interventions] can have a major effect on student success.?

So why have so few pre-kindergartens have been put in place so far? According to Bouchard, it?s a question of funding.

?After the cuts we?ve experienced, we would absolutely need new funds. We would have to hire more teachers, and have more space for children. [?] That would mean building onto existing schools or even creating new schools,? said Bouchard.

Although the FCSQ does not keep statistics on the effects of pre-kindergarten on student success, Bouchard pointed to the strides made by other programs for underprivileged children as reason for increased investment.

?In places where we put programs in place for these children, we see higher graduation rates, higher student success,? she said.

For this reason, Bouchard thinks that low-income areas should get pre-kindergarten first, and supports the CSE?s suggestion to democratize daycare for all four-year-olds.

?If the?government did this, it would send a clear message to the population of Quebec that education is a real priority.?

Quebec?s Approach- a ?Mixed Message?

Nina Howe, a research chair in Concordia?s Education department, studies children?s social and emotional development in childcare and classroom settings. She says that parental income is a very important factor in determining the kind of educational experiences children have access to in early childhood.

?For children growing up in poverty, there?s quite a large body of work now that suggests that having enriched early childhood experiences helps those children function better in school,? said Howe. ?

She sees the province?s commitment to early childhood as a ?mixed message.?

?In some ways Quebec has been a leader, in terms of providing daycare,? she said. But she worries that not all children who attend daycare are receiving educational experiences of the same quality.

Her concern lies with daycare centres that, while still subsidized by the government, operate outside the state-run system. These for-profit centres ?tend to hire the minimum number of trained teachers they need to do to meet provincial regulations, and that?s because they?re businesses,? she explained.

But teacher training, in Howe?s opinion, is key to quality.

?We don?t let teachers teach in the public schools without a teaching degree. Early childhood is a very vulnerable and a very important stage of development. Everyone who works with young children should also have?to my mind?high-quality training,? she said.

Howe thinks that Quebec has been slow to develop programs for four-year-olds, and points to Ontario, where there is pre-kindergarten for all children of this age, as an example.

What quality early childhood education gives, she explained, is a chance for children to gain important life skills?like self-discipline, cooperation and an eagerness to learn?before they begin school.

?All of these issues are really of prime importance in the early childhood years, and they are the kinds of things that carry on into how you?re going to grow up, and what individual you?re going to be.?

Source: http://thelinknewspaper.ca/article/3553

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Post-Election Stock Market Sell-Off - Business Insider

The markets are getting annihilated right now.

But the post-election sell-off phenomenon is not unusual.?

"With the S&P 500 down more than 1% this morning, the current cycle is following the typical trend of positive Election Days and weakness the day after," writes the?Bespoke Investment Group.

Here's a table showing the recent history::

Source: http://www.businessinsider.com/post-election-stock-market-sell-off-2012-11

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MOGA Android gaming controller lands at AT&T | Android Community

There are a lot of people who play games on their phone, but one of the complaints we hear coming from the ?hardcore? crowd of gamers is that smartphone controls just aren?t a suitable replacement for more traditional controllers. PowerA is looking to combine the best of both worlds with its new MOGA Android gaming controller. Officially called the MOGA Mobile Gaming System, it?s available at a ton of AT&T stores across the nation today.


To get a little more specific, MOGA is available at 1,150 AT&T stores along with AT&T?s website. MOGA is compatible with phones running Android 2.3 Gingerbread or newer, so it should work with a vast array of Android devices. If you don?t have plans to pick up a new smartphone from AT&T (or you?re not an AT&T customer), you can pick up MOGA at a number of other places, including GameStop, Best Buy, Walmart, and PowerA.com.

The MOGA features all of the things core gamers crave in a controller, including a pair of shoulder buttons, dual thumb sticks, four face buttons, and finally, start and select buttons. It connects to your phone through Bluetooth and even features a cradle to hold your device. PowerA was touting the number of companies it has making MOGA-enhanced games for Android, which includes the likes of Gameloft, Sega, and Namco Bandai.

Developers who would like to make their games compatible with MOGA can hit up PowerA for a MOGA SDK, while gamers who need to find games compatible with their new gaming peripheral can download MOGA Pivot, an app that shows you all of the MOGA enhanced games on offer. Even better is that the MOGA Pivot app is a free download from Google Play [download link]. Finally, MOGA comes with a price of $49.99, which isn?t too bad considering that first-party controllers for the Xbox 360, PS3, and Wii all cost around the same price. Are you going to pick one up?

Source: http://androidcommunity.com/moga-android-gaming-controller-lands-at-att-20121106/

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Tuesday, November 6, 2012

New findings on gene regulation and bone development

ScienceDaily (Nov. 5, 2012) ? The patients have single short fingers (metacarpals) and toes (metatarsals) and can be restricted in growth due to a shortened skeleton. This hereditary disease is called brachydactyly type E (Greek for short fingers). Three years ago Dr. Philipp G. Maass from the research group of Professor Friedrich C. Luft at the Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charit? Medical Faculty and the Max Delbr?ck Center for Molecular Medicine (MDC) in Berlin-Buch, discovered an epigenetic mechanism, which, when dysregulated, causes this condition. Now, together with Dr. Sylvia B?hring (ECRC) he was able to show how this epigenetic regulator functions and influences the development of the skeleton and the extremities. Also, he shed light on a new principle of gene regulation.

The research is reported in the Journal of Clinical Investigation.

The gene causing brachydactyly type E (BDE) is PTHLH (the abbreviation stands for parathyroid hormone like hormone), and belongs to a group of genes that regulate the development of cartilage and determine subsequent skeletal structure. The researchers investigated two families with BDE. The patients exhibit shortened metacarpals, involved in forming the hands and feet, but had no other clinical symptoms.

Up to now, more than ten different forms of brachydactyly are known. The features of the hands and feet are variable depending upon which type of brachydactyly a patient has. Sometimes, the brachydactyly can be associated with hypertension, mental retardation, or other medical problems.

Several new findings

The gene PTHLH is located on chromosome 12, one of the 46 chromosomes of the human genome. The gene exerts considerably influence on cartilage during development and early life. However, little was known about the regulation of this gene. Now, Dr. Maass, Dr. B?hring and Professor Luft have detected an epigenetic regulator for the gene PTHLH on chromosome 12 and in the course of their research made several new findings.

First, they could show, that the gene regulator interacts with genes over very long distances on the same chromosome (cis) and that it also is able to regulate genes on other chromosomes (trans). Thus, the tongue-twister name for this regulator: cis and trans-chromosomal communicator acting through DNA and noncoding RNA (CISTR-ACT).

Second, the team showed that because of a balanced translocation, CISTR-ACT is misplaced, so that the regulator no longer can properly influence PTHLH function.

Third, CISTR-ACT encodes a so-called long noncoding RNA that participates in the regulatory functions. This finding encompasses a new principle in gene regulation. Epigenetics refers to inherited mechanisms that occur without alterations in the DNA gene sequence. In this form of BDE, no change in the DNA sequence of coding genes is responsible for the condition.

Back to the first finding, the epigenetic regulator CISTR-ACT on chromosome 12 manages to get in touch with the gene PTHLH over a distance of 24 million base pairs. "The largest ever measured distance between a gene regulator and a gene on the same chromosome was around one million base-pairs," explains Dr. Maass. Furthermore, CISTR-ACT regulates another developmental gene (SOX9) on chromosome 17. "This finding is extraordinary," comments Dr. Maass.

How is this regulation possible? The researchers found the solution at the chromatin level, in which the chromosomes are densely packed. "Just imagine a ball of wool in which different threads actually touch each other at special points. At one point you have the gene, the other point symbolizes the gene regulator. "It is through this physical contact that CISTR-ACT regulates certain genes such as PTHLH very precisely in a specific tissue," Dr. Maass and Dr. B?hring explain. The researchers could thus show that huge chromosomal loops build up on chromosome 12. Moreover, the epigenetic regulator, CISTR-ACT on chromosome 12 is somehow able to get in touch with its target SOX9 on chromosome 17.

Translocation on different chromosomes

Furthermore, Dr. Maass and Dr. B?hring could show that due to the balanced translocation involving chromosome 4, breakpoints result in patients with BDE so that the gene PTHLH is translocated far away to chromosome 4 in one family or to chromosome 8 in another. Such chromosomal rearrangments or translocations as geneticists say, can be inherited and are not that uncommon. They are often associated with cancer in which they are acquired (somatic mutations) or they can be a congenital (genomic) disorder. Translocations change the architecture of the genome. Genes can part from their regulator and be located at different places in the genome.

Translocations also influence gene expression, that is the production of proteins which built up and maintain the body`s tissues. Dr. Maass and Dr. B?hring found out that in their patients with BDE these translocations separate the gene PTHLH from its regulator CISTR-ACT, which reduces the expression of the gene during the development of cartilage. This state-of-affairs results in the premature maturation of the cartilage cells during the development of the extremities, leading to single shortened bones in the hands or feet of the patients with BDE.

New insights into the dogma of gene regulation

"We could also enlarge the dogma of gene regulation in monogenic diseases, that is in diseases which are caused by one single gene," Dr. Maass and Dr. B?hring explain. Up until recently, scientists believed that DNA regulators residing in close proximity to their targets regulate genes.

The researchers in Berlin also showed that CISTR-ACT not only functions as a DNA-regulator, but also encodes a long non-coding RNA (lncRNA). Recently, researchers have begun looking at these lncRNA, because they appear to play an important role in organ development. Contrary to protein-coding genes these lncRNA do not produce proteins but instead serve their function in an epigenetic fashion. lncRNAs are distinguished by their length (greater than 200 nucleotides). Often, lncRNAs are encoded in many exons spread over large, intergenic DNA regions. Various diverse functions have been proposed for lncRNAs, including roles in regulating DNA metabolism, chromatin structure, and gene expression.

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The above story is reprinted from materials provided by Max Delbr?ck Center for Molecular Medicine (MDC) in Berlin-Buch.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Philipp G. Maass, Andreas Rump, Herbert Schulz, Sigmar Stricker, Lisanne Schulze, Konrad Platzer, Atakan Aydin, Sigrid Tinschert, Mary B. Goldring, Friedrich C. Luft, Sylvia B?hring. A misplaced lncRNA causes brachydactyly in humans. Journal of Clinical Investigation, 2012; 122 (11): 3990 DOI: 10.1172/JCI65508

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/rqvIqqTn12I/121105114624.htm

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Acciones de Foxconn suben un 35 pct al mejorar Citi sus expectativas del iPhone

HONG KONG (Reuters) - Las acciones del gigante de electr?nica Foxconn International Holdings (FIH), la empresa contratista de ensamble de tel?fonos m?viles, subieron hasta un 35 por ciento despu?s de que Citigroup cambiara la recomendaci?n a "comprar" y dijera que preve?a que la empresa comenzar? a ensamblar iPhones este a?o.

El informe, la primera recomendaci?n positiva de Citigroup en casi tres a?os, provoc? la subida. Las acciones han languidecido este a?o debido al cada vez menor negocio de fabricaci?n de tel?fonos ya que sus principales clientes, como Nokia, van detr?s de Apple en la carrera de los tel?fonos inteligentes.

FIH ver? un pronunciado giro de acontecimientos el a?o que viene, ya que empresas de software e Internet entrar?n en el negocio de los tel?fonos inteligentes y la empresa comenzar? a montar iPhones para Apple, dijo Citigroup.

"Amazon, Google, Microsoft, Xiaomi, Baidu, Tencent todos van a tratar de lanzar tel?fonos inteligentes y ninguno tiene una f?brica propia", dijo Citigroup, elevando su precio objetivo de FIH a 5,80 d?lares de Hong Kong y su estimaci?n de ganancias para 2013 un 134 por ciento al alza.

Las acciones de FIH, que ensambla tel?fonos para Huawei Technologies y ZTE, subieron a 3,69 d?lares de Hong Kong, su mayor incremento en un d?a.

Las acciones de FIH a?n est?n un 30 por ciento por debajo del ?ndice Hang Seng, que se ha apreciado casi un 20 por ciento este a?o.

(Informaci?n adicional de Donny Kwok en Hong Kong y Faith Hung en Taipei; Traducido por Emma Pinedo)

Source: http://news.yahoo.com/acciones-foxconn-suben-35-pct-mejorar-citi-expectativas-142439174--sector.html

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Free online money makeover course reveals how 5 financial myths have conditioned you to be broke and in debt

Did you know that consumer debt in America totals nearly $16 trillion? And CreditCard.com reports that the national average for credit card interest rates is a whopping 14.98 percent!

Did you know that consumer debt in America totals nearly $16 trillion? And CreditCard.com reports that the national average for credit card interest rates is a whopping 14.98 percent!

That?s because people have been lying to consumers, and it?s costing them a fortune and threatening their retirement.

But financial literacy expert, Anthony Manganiello, founder of DebtFreeAcademy.com and author of The Debt-Free Millionaire, blows the cover off the five money myths that are keeping consumers broke and in debt.

That?s because for decades, so-called ?financial experts??even our own well-meaning parents and mentors?have been perpetuating myths like:

1. A mortgage could be the biggest investment you?ll ever make. (Wrong! Good debt has been shoved down our throats as a ?must have.? Anthony explains how so-called ?good debt? is causing consumers to lose 10, 20, 30, even 40 percent or more every year. There?s no such thing as ?good debt?!)

2. In order to secure a solid financial future, you should ?Pay yourself first.? (No! This financial strategy is rooted in a story written almost 100 years ago. And the proponents of the pay-yourself-first philosophy are people usually trying to sell you investments and pay THEM first.).

3. You need to use a budget to get ahead financially. (Please don?t! Budgeting can create a false sense of financial security. And while budgeters think they?re doing well, their financial future is slowly being stolen from them?one paycheck at a time.)

4. If you want the best for your kids, you?d better start saving for their college education right away. (False! Of course, parents want what?s best for their children. But socking away the dough NOW for their college education is not a good idea.)

5. Making more money can help you achieve your financial goals. (Sounds good, but it?s another myth! Landing a better-paying job or earning more income is always tempting. The truth is, extra income could push you from the financial frying pan into the fire. Ouch!)

These five financial myths that have been handed down in ?gospel-like? fashion are?and will continue to?cost Americans a fortune. But these common money philosophies only teach one side of a very two-sided coin. And it?s the other side of the coin that?s costing consumers thousands of dollars each month.

But with the all-new DebtFree Academy, learning the truth about these five financial myths as well as learning about becoming completely debt-free is?free!

With a free membership in the DebtFree Academy, you will learn the truth about those five financial myths. And once you?ve been ?dehypnotized? you?ll learn?

1. What debt and credit really are
2. How to discover your true financial position
3. How to become completely debt free (even if you can?t pay your bills right now!)
4. How to retire rich
5. How to create a ?Wealth Accumulation? mentality

And so much more. Learn how at DebtFreeAcademy.com.

Anthony Manganiello is an author, speaker, and entrepreneur who has spent the last two decades in the research and development?including the investment of millions of dollars, and tens of thousands of interviews with every day people looking for help with their debt and credit problems. The end result was the creation of the Cash-Flow Analysis?, the Cash-Flow Dashboard? the book,?The Debt-FREE Millionaire: Winning Strategies to Creating Great Credit and Retiring Rich, and www.DebtFreeAcademy.com.

Contact:
Anthony Manganiello
Debt Free Academy
450 Phoenix, AZ 80516
608-306-0197
anthonym@debtfreeacademy.com
http://www.debtfreeacademy.com/

Source: http://www.webnewswire.com/content/free-online-money-makeover-course-reveals-how-5-financial-myths-have-conditioned-you-be

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